Announcement of the 2022 Nobel Prize in Chemistry
A copy of the press release, illustrations, and links to where you can read more about the work that led to the prize, and articles about the work are posted below for your convenience.
PRESS RELEASE (10-05-2022)
NOBEL ASSEMBLY
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2022 to
Carolyn R. Bertozzi
Stanford University, CA, USA
Morten Meldal
University of Copenhagen, Denmark
K. Barry Sharpless
Scripps Research, La Jolla, CA, USA
“for the development of click chemistry and bioorthogonal chemistry”
It just says click – and the molecules are coupled together
The Nobel Prize in Chemistry 2022 is about making difficult processes easier. Barry Sharpless and Morten Meldal have laid the foundation for a functional form of chemistry – click chemistry – in which molecular building blocks snap together quickly and efficiently. Carolyn Bertozzi has taken click chemistry to a new dimension and started utilising it in living organisms.
Chemists have long been driven by the desire to build increasingly complicated molecules. In pharmaceutical research, this has often involved artificially recreating natural molecules with medicinal properties. This has led to many admirable molecular constructions, but these are generally time consuming and very expensive to produce.
“This year’s Prize in Chemistry deals with not overcomplicating matters, instead working with what is easy and simple. Functional molecules can be built even by taking a straightforward route,” says Johan Åqvist, Chair of the Nobel Committee for Chemistry.
Barry Sharpless – who is now being awarded his second Nobel Prize in Chemistry – started the ball rolling. Around the year 2000, he coined the concept of click chemistry, which is a form of simple and reliable chemistry, where reactions occur quickly and unwanted by-products are avoided.
Shortly afterwards, Morten Meldal and Barry Sharpless – independently of each other – presented what is now the crown jewel of click chemistry: the copper catalysed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use. Among many other uses, it is utilised in the development of pharmaceuticals, for mapping DNA and creating materials that are more fit for purpose.
Carolyn Bertozzi took click chemistry to a new level. To map important but elusive biomolecules on the surface of cells – glycans – she developed click reactions that work inside living organisms. Her bioorthogonal reactions take place without disrupting the normal chemistry of the cell.
These reactions are now used globally to explore cells and track biological processes. Using bioorthogonal reactions, researchers have improved the targeting of cancer pharmaceuticals, which are now being tested in clinical trials.
Click chemistry and bioorthogonal reactions have taken chemistry into the era of functionalism. This is bringing the greatest benefit to humankind.
The illustrations are free to use for non-commercial purposes. Attribute ”© Johan Jarnestad/The Royal Swedish Academy of Sciences”
Popular science background: Their functional chemistry works wonders (pdf)
Scientific Background: Click chemistry and bioorthogonal chemistry (pdf)
Carolyn R. Bertozzi, born 1966 in USA. PhD 1993 from UC Berkeley, CA, USA. Anne T. and Robert M. Bass Professor at Stanford University, CA, USA.
Morten Meldal, born 1954 in Denmark. PhD 1986 from Technical University of Denmark, Lyngby, Denmark. Professor at University of Copenhagen, Denmark.
K. Barry Sharpless, born 1941 in Philadelphia, PA, USA. PhD 1968 from Stanford University, CA, USA. W. M. Keck Professor at Scripps Research, La Jolla, CA, USA.
Prize amount: 10 million Swedish kronor, to be shared equally between the Laureates.
INTERVIEWS "Methods to connect molecules in essentially the same way you build legos." Chemistry prize 2022.
Morten Meldal: “Reality is much more complex than we, as chemists, are able to imagine”
Carolyn Bertozzi: “When the world is in trouble, chemistry comes to the rescue”
News Articles This section will be updated over the next several days --editor.
• 2022 Nobel Prize in Chemistry Awarded for a New Way of Building Molecules [Scientific American]
• Simple, reliable reactions that 'click' molecules together garner chemistry Nobel [Science: American Association for the Advancement of Science]
• Nobel prize for three chemists who made molecules 'click' [PHYS.ORG]
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Published at 9:35am on Wednesday, October 05, 2022
Author: Bobby Coggins
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